Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine
P Plenge, ET Mellerup, H Laursen - Progress in Neuro …, 1990 - Elsevier
1. Regional distribution of the serotonin transport complex was studied in 12 different brain
areas from human brains. The serotonin uptake complex was measured with 3 H-
paroxetine, and 3 H-imipramine. The binding site density was highest in the nucleus of
raphe, medium in the basal ganglia, and lowest in cortical areas. The specific binding
measured with 3 H-paroxetine and 3 H-citalopram was compared with the high affinity 3 H-
imipramine binding determined with either 100 μM 5HT or 1 μM imipramine as non specific …
areas from human brains. The serotonin uptake complex was measured with 3 H-
paroxetine, and 3 H-imipramine. The binding site density was highest in the nucleus of
raphe, medium in the basal ganglia, and lowest in cortical areas. The specific binding
measured with 3 H-paroxetine and 3 H-citalopram was compared with the high affinity 3 H-
imipramine binding determined with either 100 μM 5HT or 1 μM imipramine as non specific …
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